Research Areas
The structure and function of DNA topoisomerases as the basis for discovery of antibacterial and anticancer drug leads from synthetic molecules and natural products.
Organizer of international conference on Topoisomerases in Biology and Medicine
- The structure and function of DNA topoisomerases as the basis for discovery of antibacterial and anticancer drug leads from synthetic molecules and natural products
View Dr. Tse-Dinh's peer-reviewed publications
Publications with undergraduate coauthors (*)
- Garcia PK, *Martinez Borrero R, Annamalai T, *Diaz E, *Balarezo S, Tiwari PB, Tse-Dinh YC. Localization of Mycobacterium tuberculosistopoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4. Front Microbiol. 2022;13:1032320.
- Diaz B, *Mederos C, Tan K, Tse-Dinh YC. Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination. Int J Mol Sci. 2022;23(15):8709.
- Sandhaus S, Annamalai T, Welmaker G, Houghten RA, *Paz C, Garcia PK, *Andres A, Narula G, Rodrigues Felix C, Geden S, Netherton M, Gupta R, Rohde KH, Giulianotti MA, Tse-Dinh YC. Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents. Antimicrob Agents Chemother. 2016;60(7):4028-36.
Education
- Hollins University, Virginia BA 1977 Chemistry
- Harvard University, Massachusetts PhD 1982 Biological Chemistry